Nicotinamide Adenine Dinucleotide (NAD+) is a dinucleotide compound made of two nucleotides connected via the phosphate groups. One nucleotide contains nicotinamide while the other has adenine base. Its existence is in two forms, the oxidized and the reduced form.
Nicotinamide Adenine Dinucleotide’s role in your body is to protect it from the aging process by regulating factors such as failing mitochondria, DNA damage, inflammation, and minimizing chemical stress. The levels of this coenzyme decline with age, resulting in a shortage of energy, which reduces the body’s functionality and ability to retain its youthful state. Research shows that supplementing your body with an antecedent of NAD referred to as nicotinamide riboside can increase the longevity.
Let’s review five anti-aging benefits of this essential metabolite:
1. It Works to Repair DNA
DNA is highly susceptible to damage, which can result in DNA strands breaking and essential genes mutating. Continuous DNA damage is a significant contributor to aging and may result in life-shortening ailments such as low immunity and cancer.
When DNA damage happens, the PARP-1 enzyme is activated. This coenzyme repairs DNA, and while doing so, it consumes a lot of NAD and eventually depletes it. Replenishing this coenzyme facilitates DNA repair, thereby preventing cell degeneration and diseases such as cancer.
2. Moderates Immune Cell Signaling
Immune cells lose focus as you continue aging, thus becoming overactive and possibly resulting in a rise in autoimmune diseases and other infections. This process best referred to as Immunosenescence relates to energy balance and mitochondrial functions, all of which rely on Nicotinamide Adenine Dinucleotide activity.
A sufficient level of this critical metabolite within the cells facilitates youthful cellular energy, which is essential in building a defense against autoimmune diseases and infections and fending off Immunosenescence.
3. Induction of Energy-Intensive Enzymes
Aging is mostly associated with loss of energy in the cells, resulting in the decline of ATP levels and less energy fuel.
A significant cause of this energy loss is the failure of the electron transport chain’s efficiency which is the primary pathway for energy extraction from food, a process is critical for this metabolite. The loss of this pathway causes diseases such as diabetes, obesity and bone loss. This enzyme is vital in promoting crucial enzymes that serve in the extraction of energy and preserving youthful cell function which reduces physiological decline and protects against age-related ailments.
4. Facilitates Energy Production
It plays a significant role in channeling energy from food to ATP fuel required by cells. It is also a functional signaling molecule in PARP-1 and sirtuins, both of which are energy production processes. High Nicotinamide Adenine Dinucleotide levels activate sirtuins, enabling them to perform their stress and metabolic protective responses, thereby leading to longevity.
5. NAD Activates Sirtuins
Sirtuins are proteins that regulate cellular aging since they influence essential functions such as inflammatory responses and DNA repair as well as apoptosis. Examples of these include quercetin and resveratrol. Activation of these proteins is vital in preserving the brain’s aging function and fighting cardiovascular diseases, processes which all rely on sufficient metabolite level.
NAD has major anti-aging benefits to the body. It improves fundamental cell anti-aging functions, which when impaired result hasten aging which leads to disorders such as osteoporosis and Alzheimer’s. It’s crucial to restore the levels of this essential metabolite to maintain our youthful look.
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